A twelve-year-old female entire Lurcher-cross dog presented for investigation of an acute onset of cluster seizures and elevation of the liver enzymes. Physical examination was unremarkable; neurological examination was suggestive of diffuse forebrain involvement. Abdominal ultrasound documented a hyperechoic hepatic parenchyma, bilateral adrenomegaly and a splenic irregular hypoechoic nodule. Splenic cytology revealed inflammation and numerous fungal elements. Low dose dexamethasone suppression test suggested the diagnosis of hyperadrenocorticism. Magnetic resonance (MRI) of the brain revealed multifocal cerebral lesions. Anti-fungal therapy was started, but no clinical response was seen and euthanasia was elected. Postmortem examination confirmed the diagnosis of systemic mycosis with involvement of the brain and liver. Systemic mycoses are uncommonly reported in the UK, but this case report raises the importance of considering fungal encephalitis as a differential diagnosis in dogs with seizures and in particular in dogs with hyperadrenocorticism, as this endocrinopathy may act as a predisposing factor.
- fungal diseases
Statistics from Altmetric.com
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement All data relevant to the study are included in the article.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.