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Hypercalcaemia in a dog with lymphoma without increases in parathyroid hormone, parathyroid hormone-related protein and vitamin D metabolites concentrations
  1. Alex Mullany1,
  2. Abigail Waddington1 and
  3. Richard J Mellanby2
  1. 1Pet Emergency Treatment Services Ltd, Maidstone, UK
  2. 2Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush Veterinary Campus, Roslin, Midlothian, UK
  1. Correspondence to Dr Richard J Mellanby; richard.mellanby{at}


Lymphoma is one of the most common causes of hypercalcaemia in dogs. Typically, the hypercalcaemic state is driven by ectopic production of parathyroid hormone-related protein by the malignant lymphoma cells. In this case report, the authors describe the diagnosis of lymphoma in a dog with hypercalcaemia which had a plasma parathyroid hormone-related protein concentration within the reference range. Furthermore, circulating concentrations of the two other main hormones which are known to increase serum calcium concentrations, namely parathyroid hormone and 1,25 dihydroxyvitamin D, were also below the upper limits of their respective reference ranges. This case report highlights that hypercalcaemia is not invariably mediated by increases in circulating concentrations of parathyroid hormone-related protein. In addition, it emphasises the need to further investigate the pathophysiology of malignancy-related hypercalcaemia in dogs.

  • dogs
  • lymphoma
  • hypercalcaemia
  • parathyroid hormone related protein
  • vitamin D
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  • Contributors AM and AW managed case and prepared case summary. RJM advised on case management and drafted manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests RJM has received consultancy fees and a research grant from Hill's Pet Nutrition

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article.

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