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Case of multiple myeloma with cutaneous involvement and aberrant CD3 expression
  1. Luca Schiavo1,
  2. Stefano Di Palma2 and
  3. Sara Verganti3
  1. 1Department of Small Animals, Animal Health Trust, Newmarket, Suffolk, UK
  2. 2Department of Small Animal Oncology, Aptuit Srl, Verona, Italy
  3. 3Department of Small Animal Oncology, Animal Health Trust, Newmarket, Suffolk, UK
  1. Correspondence to Dr Luca Schiavo; lucaschiavo256{at}


A six-year-old golden retriever presented for a fast-growing mass at the level of the left mandibular area. Cytological evaluation was consistent with an anaplastic round cell neoplasm. CT scan and abdominal ultrasound showed the presence of a large mass affecting the left mandibular salivary gland, several subcutaneous nodules and generalised intra-abdominal lymphadenomegaly. The mandibular mass was surgically removed, and histopathology and immunohistochemistry were compatible with plasma cell tumour with aberrant CD3 expression. Complete staging led to the diagnosis of multiple myeloma with skin and salivary gland involvement. After receiving one dose of vincristine, the dog was started on melphalan/prednisolone protocol. After initial improvement, the dog showed signs of progressive disease and was euthanased 35 days after starting treatment due to severe clinical deterioration. Postmortem examination showed infiltration by neoplastic cells in several organs including the heart, the conjunctiva and some abdominal organs.

  • multiple myeloma
  • oncology
  • CD3
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  • Contributors LS was responsible in writing the paper and recruit the necessary information from the different areas. SDP performed the histopathology and immunohistochemistry and supervise the writing of the paper. SV supervised the clinical part as well as the writing of the paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article.

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