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Spinal cord clear cell meningioma in a dog
  1. Nicholas Robert James Clarke,
  2. Georgina Louise Harris,
  3. Oliver Greville-Heygate,
  4. Fernando Constantino-Casas and
  5. Paul Freeman
  1. Department of Veterinary Medicine, Queen's Veterinary School Hospital, Cambridge, UK
  1. Correspondence to Dr Nicholas Robert James Clarke; nicholasrjclarke{at}


A five-year-old, male entire Jack Russell terrier presented for a two-month history of ambulatory paraparesis lateralised to the left. Neurological examination localised to an L4–S3 myelopathy. MRI revealed an equivocal intramedullary lesion at the level of the L4–L5 disc space occupying 80 per cent of the spinal cord area. The mass was surgically resected. Histopathology confirmed the mass to be consistent with a meningioma in which a high proportion of neoplastic cells exhibited clear cytoplasm that stained positively with periodic acid-Schiff and was diastase-sensitive. This mass was assigned grade II/atypical (World Health Organization human system) based on the predominant clear cell morphology and a mitotic count of 10 mitotic figures in 10 high-power fields. To the authors’ knowledge, this is the first reported case of a clear cell meningioma in a dog.

  • clear cell meningioma
  • dog
  • intraspinal
  • neuropathology
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  • Contributors NRJC prepared and wrote the final manuscript with feedback from all other authors. OG-H acquired the microscopy images used as figures and specifically wrote the histopathology report section of the manuscript. OG-H and FC-C both analysed the original histopathology samples, providing the histopathological diagnosis. GLH and PF both worked up the case clinically and provided treatment, including surgery, and follow-up to the patient.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement There are no data in this work.

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