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Rodents and lagomorphs
Disparate histopathology of sebaceous adenitis in a rabbit
  1. Nicole A Heinrich1,
  2. Douglas Chamroeun2 and
  3. Erin Locke3
  1. 1McKeever Dermatology Clinics, Eden Prairie, Minnesota, USA
  2. 2Animal Science, University of Minnesota System, Minneapolis, Minnesota, USA
  3. 3Antech Diagnostics, Fountain Valley, California, USA
  1. Correspondence to Dr Nicole A Heinrich; heinrichderm{at}


A 13-month-old, spayed, female rex rabbit presented with mildly pruritic, progressive patches of alopecia, erythema and scaling of the head, trunk and legs of five months’ duration. Initial skin biopsy was consistent with cutaneous epitheliotropic lymphoma, but a follow-up skin biopsy and response to therapy revealed that the rabbit actually had sebaceous adenitis. Nearly one year after presentation, the rabbit’s clinical signs remained well controlled. This case demonstrates the importance of interpreting histopathology in light of history, physical examination, supportive tests and response to therapy. It also demonstrates how cutaneous lesions may evolve over time and that serial biopsies may be required to achieve a diagnosis. Finally, this case suggests that there may be histopathological overlap between cutaneous epitheliotropic lymphoma and sebaceous adenitis in rabbits.

  • dermatology
  • histopathology
  • rabbits
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  • Contributors NAH organised, wrote and edited the majority of the case report. DC organised and summarised the treatment timeline and provided clinical images. EL wrote the histopathological descriptions and contributed histopathology images. All authors read, evaluated and approved the final document.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article.

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