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Diabetes mellitus and anterior uveitis secondary to the systemic effects of a functional adrenal tumour in a cat
  1. Lauren E Toleson,
  2. Amy Tamulevicus and
  3. Louisa Rahilly
  1. Emergency/Critical Care, Cape Cod Veterinary Specialists, Buzzards Bay, Massachusetts, USA
  1. Correspondence to Dr Lauren E Toleson; lauren.toleson{at}


A 10-year-old, neutered male domestic longhair (DLH) cat presented for evaluation of cloudiness in the anterior chamber of both eyes. He was diagnosed with anterior uveitis, chorioretinitis and systemic hypertension. An abdominal ultrasound (AUS), adrenal panel and urine metanephrine fractionation test were consistent with an oestradiol-secreting adrenal tumour. Additional testing was consistent with diabetes mellitus (DM) and hyperthyroidism. A right adrenalectomy was performed and the patient was subsequently determined to have hypoadrenocorticism, though mineralocorticoid deficiency never developed. DM and systemic hypertension resolved following adrenalectomy. The patient was reported to have a good quality of life with steroid supplementation. A hepatic mass, cytologically consistent with metastatic disease, was discovered on AUS 2 years following adrenalectomy. The patient subsequently developed congestive heart failure secondary to hypertrophic cardiomyopathy, and humane euthanasia was performed.

  • adrenal gland
  • Adrenal mass
  • adrenocortical adenoma
  • adrenalectomy
  • oestradiol-secreting
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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article.

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