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Pituitary macroadenoma leading to hypogonadism in a dog
  1. Camilla Tørnqvist-Johnsen1,
  2. Glynn A Woods1,
  3. Yi Lin Tan1,
  4. Tobias Schwarz1,
  5. Laura Blackwood2,
  6. Richard J Mellanby1 and
  7. Silke Salavati1
  1. 1Division of Veterinary Clinical Studies, Hospital for Small Animals, The Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Midlothian, UK
  2. 2University of Liverpool Institute of Veterinary Science, Liverpool, Merseyside, UK
  1. Correspondence to Dr Camilla Tørnqvist-Johnsen; c.t.johnsen{at}


A six-year-old male entire dachshund presented for investigation of decreased testicular size noted over the last six months and progressive lethargy for two months. Apart from small symmetrical testicles and a small prostate gland, physical examination revealed no abnormalities. Neurological examination was repeatably normal. Extensive diagnostic investigations for extracranial disease with a focus on reproductive and metabolic-endocrine disorders revealed no abnormalities. Decreased testosterone (0.2 nmol/l) with inappropriately low luteinising hormone (<0.7 iu/l) and follicle stimulating hormone (2.1 ng/ml) in comparison with six other male entire dogs was detected. Based on the exclusion of all other conditions, intracranial disease was suspected. MRI of the head revealed a 2 x 1.8 x 1.5 cm mass arising from the pituitary fossa. Radiotherapy (12 fractions of 4 Gy, three days per week for four weeks, three-dimensional conformal plan, 6 MV) and pain relief resulted in resolution of lethargy. Twelve months after initial diagnosis, the dog was asymptomatic, while the testicles remained small.

  • testicular atrophy
  • hypothalamus pituitary gonadal axis
  • pituitary macroadenoma
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  • Contributors CT-J, SS, RJM, TS and YLT were involved in seeing the case, as was LB when the case was referred for radiation. RJM ordered in test kits and organised the comparative population of six healthy adult dogs from the biobank, as well as images of the case for the report. CT-J, GW and SS worte the first manuscript, and CT-J and SS were the main drivers of the final version. YLT extracted the initial images of the patients and wrote the imaging descriptions for the first draft of the case report and TS extracted the final images (including normal and images from Liverpool) and wrote descriptions for the final draft of the case report. LB contributed to treatment information as this was done at her institution. All authors reviewed the final manuscript and suggested changes which were implemented.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article.

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