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Bisalbuminemia in a dog with leishmaniosis after anti-Leishmania therapeutic protocol administration: a rare condition detected in the electrophoretogram
  1. Sergio Villanueva-Saz1,
  2. Cecilia Ballesté2,
  3. Antonio Fernández Casasnovas3,
  4. Andrés Yzuel Estevez4 and
  5. Maria Teresa Verde Arribas3
  1. 1Pharmacology and Physiology Department – Clinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, Zaragoza, Spain
  2. 2Centre Veterinari Petjades, Barcelona, Spain
  3. 3Animal Pathology Department – Clinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, Zaragoza, Spain
  4. 4Clinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, Zaragoza, Spain
  1. Correspondence to Dr Sergio Villanueva-Saz; svs{at}


A 5-year-old spayed, crossbred female dog was referred for a unilateral nosebleed of 4 months’ duration. Rhinoscopy revealed significant inflammation of the nasal mucosa compatible with severe rhinitis. On the right nostril, the presence of a white patch on the mucosa was observed and a biopsy was taken. Histopathology revealed a granulomatous inflammation with the presence of neutrophils and lymphocytes. Some macrophages contained small oval microorganisms compatible with Leishmania species. The presence of Leishmania infantum was confirmed by specific immunohistochemistry, showing stained intracellular microorganisms. Abnormal clinicopathological findings included mild anaemia and hyperglobulinemia with polyclonal gammopathy. Moderate amount of antibodies to L. infantum were detected by ELISA in serum. An anti-Leishmania therapeutic protocol was established with allopurinol and meglumine antimoniate, and 4 months later, a follow-up examination was performed showing improvements in laboratory parameters with the exception of the presence of bisalbuminemia.

  • leishmaniasis
  • dogs
  • vector-borne diseases
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  • Contributors All authors made substantial contributions. CB managed the case. SVS was responsible for image acquisition and interpretation. AFC and MTVA performed the laboratory analyses. CB, AYE and SVS drafted the manuscript. All authors participated in critically appraising the manuscript and revising it for intellectual content. All authors gave final approval of the completed manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement No additional data are available.

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