TABLE 2:

Summary of treatment, lymph node measurements and eosinophil counts

Days from treatment initiationRight prescapular lymph node longest diameter (cm)Response (RECIST)*Eosinophil count (×103/µl); reference interval: 0.0–0.75×103/µlPrevious cycle treatment(s)
011Initial baseline23.96None
77.5PR3.68Prednisone 32 mg/m2 orally every 24 hours
154.5PR0.61Vinblastine 3 mg/m2 intravenously
Prednisone 32 mg/m2 orally every 24 hours
221.1CR1.69Vinblastine 2.7 mg/m2 intravenously
Prednisone 25 mg/m2 orally every 24 hours
551.2CR0.08Toceranib 2.4 mg/kg orally every 48 hours
Prednisone 25 mg/m2 orally every 24 hours
901.3CR0.38Toceranib 2.45 mg/kg orally M, W, F
Prednisone 17 mg/m2 orally every 24 hours
1186.4PD
New baseline
5.96Toceranib 2.45 mg/kg orally M, W, F
Prednisone 17 mg/m2 orally T, Th, Sa
1256.9SD2.42Vinblastine 2.7 mg/m2 intravenously
Prednisone 34 mg/m2 orally every 24 hours
1339.4PD
New baseline
5.50Vinblastine 2.7 mg/m2 intravenously
Prednisone 34 mg/m2 orally every 24 hours
15310.8SD1.73Lomustine 73 mg/m2 orally
Prednisone 34 mg/m2 orally every 24 hours
17411.2SD2.01Lomustine 77 mg/m2 orally
Prednisone 34 mg/m2 orally every 24 hours
19510.7SD4.05Lomustine 77 mg/m2 orally
Prednisone 34 mg/m2 orally every 24 hours
21711.9PD2.29Lomustine 78 mg/m2 orally
Prednisone 35 mg/m2 orally every 24 hours
23713.5PD
New baseline
3.44Lomustine 78 mg/m2 orally
Prednisone 35 mg/m2 orally every 24 hours
25013.0SD11.98Vinorelbine 15 mg/m2 intravenously
Prednisone 18 mg/m2 orally every 24 hours
26513.2SD8.81Vinorelbine 15 mg/m2 intravenously
Prednisone 18 mg/m2 orally every 24 hours
  • *See Table 1 for RECIST response criteria.

  • F, Friday; M, Monday; Sa, Saturday; T, Tuesday; Th, Thursday; W, Wednesday of each week.